Measurement of charm and beauty photoproduction from inclusive secondary vertexing at HERA-II ZEUS Collaboration Abstract Photoproduction of beauty and charm quarks in events with two jets has been measured with the ZEUS detector at HERA using an integrated luminosity of ~130 pb-1. The beauty and charm content was extracted using the decay-length significance of the b and c hadrons and the invariant mass of the decay vertices. Differential cross sections as a function of pT(Jet) and eta(Jet) are compared with the Pythia leading order plus parton shower (LO+PS) Monte Carlo and QCD predictions calculated at next-to-leading order.